Drawing on Dr. Jae Kim’s experience with implementing and leading POCUS programs in two U.S. children’s hospitals, this article provides a five-step roadmap to adoption of this imaging modality to improve the safety and quality of care in the NICU. Physician training, the most active uses, and opportunities for POCUS in neonatal medicine and case examples are discussed. The article also provides guidance on selecting a point-of-care ultrasound system for neonatology.