Case: Ectopic Pregnancy - Part 2

Case: Ectopic Pregnancy - Part 2

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This video details how bedside ultrasound can help emergency medicine professionals visualize and diagnose various presentations of ectopic pregnancy, as well as differentiate between an ovarian cyst and an ectopic pregnancy.
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<p begin="00:00:13.615" end="00:00:15.133" style="s2">- Hello, my name is Phil Perera</p>
<p begin="00:00:15.133" end="00:00:17.205" style="s2">and I'm the Emergency<br />Ultrasound Coordinator</p>
<p begin="00:00:17.205" end="00:00:20.167" style="s2">at the New York Presbyterian<br />Hospital in New York City</p>
<p begin="00:00:20.167" end="00:00:22.834" style="s2">and welcome to SoundBytes Cases.</p>
<p begin="00:00:23.896" end="00:00:26.515" style="s2">This module is ectopic pregnancy part two,</p>
<p begin="00:00:26.515" end="00:00:27.795" style="s2">where we'll go over the multiple</p>
<p begin="00:00:27.795" end="00:00:31.212" style="s2">ultrasound presentation<br />of ectopic pregnancies.</p>
<p begin="00:00:31.212" end="00:00:32.502" style="s2">Ectopic pregnancy is one of those</p>
<p begin="00:00:32.502" end="00:00:34.292" style="s2">conditions that we'll not infrequently</p>
<p begin="00:00:34.292" end="00:00:37.324" style="s2">encounter in a busy EM practice.</p>
<p begin="00:00:37.324" end="00:00:38.662" style="s2">The most common presentation of</p>
<p begin="00:00:38.662" end="00:00:41.488" style="s2">an ectopic pregnancy<br />will be an empty uterus,</p>
<p begin="00:00:41.488" end="00:00:44.790" style="s2">with or without free fluid<br />within the pelvic cul de sac</p>
<p begin="00:00:44.790" end="00:00:46.782" style="s2">or surrounding the uterus.</p>
<p begin="00:00:46.782" end="00:00:48.665" style="s2">We may be actually able to visualize</p>
<p begin="00:00:48.665" end="00:00:50.904" style="s2">the ectopic as a Bagel sign,</p>
<p begin="00:00:50.904" end="00:00:54.294" style="s2">which constitutes a<br />thickened Fallopian tube.</p>
<p begin="00:00:54.294" end="00:00:56.051" style="s2">Other presentations of ectopics</p>
<p begin="00:00:56.051" end="00:00:58.174" style="s2">include a complex pelvic mass</p>
<p begin="00:00:58.174" end="00:01:00.763" style="s2">with a ring of fire on Doppler sonography,</p>
<p begin="00:01:00.763" end="00:01:03.962" style="s2">hemosalpinx or blood<br />within the Fallopian tube</p>
<p begin="00:01:03.962" end="00:01:05.815" style="s2">or we may be actually able to visualize</p>
<p begin="00:01:05.815" end="00:01:08.232" style="s2">the live ectopic in the adnexa,</p>
<p begin="00:01:08.232" end="00:01:11.741" style="s2">with a fetal pole and/or heartbeat.</p>
<p begin="00:01:11.741" end="00:01:14.313" style="s2">Here's a transvaginal long axis ultrasound</p>
<p begin="00:01:14.313" end="00:01:16.677" style="s2">for a woman who presented<br />with lower abdominal pain</p>
<p begin="00:01:16.677" end="00:01:18.873" style="s2">and a positive pregnancy test.</p>
<p begin="00:01:18.873" end="00:01:21.661" style="s2">Notice the uterus, as shown<br />in the long axis view,</p>
<p begin="00:01:21.661" end="00:01:24.861" style="s2">without an appreciable<br />intrauterine pregnancy</p>
<p begin="00:01:24.861" end="00:01:26.084" style="s2">and notice that it's surrounded</p>
<p begin="00:01:26.084" end="00:01:28.140" style="s2">by a large amount of free fluid.</p>
<p begin="00:01:28.140" end="00:01:30.590" style="s2">That dark or anechoic area surrounding</p>
<p begin="00:01:30.590" end="00:01:32.793" style="s2">the uterus both anteriorly to the left,</p>
<p begin="00:01:32.793" end="00:01:35.668" style="s2">posteriorly in the cul<br />de sac to the right.</p>
<p begin="00:01:35.668" end="00:01:37.893" style="s2">That is the presence of fresh blood.</p>
<p begin="00:01:37.893" end="00:01:39.977" style="s2">Notice also the presence of blood clots</p>
<p begin="00:01:39.977" end="00:01:43.869" style="s2">anteriorly or to the left,<br />that more echogenic area.</p>
<p begin="00:01:43.869" end="00:01:46.298" style="s2">So, given the absence of<br />an intrauterine pregnancy,</p>
<p begin="00:01:46.298" end="00:01:48.722" style="s2">we decided to scan out to the adnexa</p>
<p begin="00:01:48.722" end="00:01:50.332" style="s2">and notice here, the presence of</p>
<p begin="00:01:50.332" end="00:01:54.030" style="s2">a Bagel sign of a tubal ectopic pregnancy.</p>
<p begin="00:01:54.030" end="00:01:56.354" style="s2">We see fresh fluid here, above the Bagel,</p>
<p begin="00:01:56.354" end="00:01:58.594" style="s2">to the right, blood clot to the left</p>
<p begin="00:01:58.594" end="00:01:59.970" style="s2">and the more hyperechoic</p>
<p begin="00:01:59.970" end="00:02:03.175" style="s2">or lighter Bagel sign in<br />the middle of the image.</p>
<p begin="00:02:03.175" end="00:02:04.839" style="s2">Occasionally it can be<br />difficult to discern</p>
<p begin="00:02:04.839" end="00:02:07.744" style="s2">the Bagel sign of a Fallopian tube ectopic</p>
<p begin="00:02:07.744" end="00:02:10.696" style="s2">from an ovarian cyst, as<br />show here to the right.</p>
<p begin="00:02:10.696" end="00:02:13.087" style="s2">But lets look closer<br />at the two video clips</p>
<p begin="00:02:13.087" end="00:02:14.836" style="s2">and notice that the Bagel sign</p>
<p begin="00:02:14.836" end="00:02:17.357" style="s2">has a more hyperechoic<br />or bright appearance,</p>
<p begin="00:02:17.357" end="00:02:19.480" style="s2">with the single hole more in the middle.</p>
<p begin="00:02:19.480" end="00:02:22.626" style="s2">Notice that the ovarian cyst<br />has a different appearance,</p>
<p begin="00:02:22.626" end="00:02:24.849" style="s2">with multiple small follicular cysts</p>
<p begin="00:02:24.849" end="00:02:26.778" style="s2">to the outer portion of the ovary</p>
<p begin="00:02:26.778" end="00:02:30.043" style="s2">and a single midline corpus luteum cyst.</p>
<p begin="00:02:30.043" end="00:02:32.770" style="s2">Very different than the Bagel sign.</p>
<p begin="00:02:32.770" end="00:02:34.990" style="s2">Here's another patient<br />with an ectopic pregnancy</p>
<p begin="00:02:34.990" end="00:02:37.857" style="s2">in a different presentation of ectopic.</p>
<p begin="00:02:37.857" end="00:02:40.284" style="s2">We're scanning here from<br />the more midline uterus,</p>
<p begin="00:02:40.284" end="00:02:43.690" style="s2">as show there to the left,<br />out to the right adnexa</p>
<p begin="00:02:43.690" end="00:02:45.983" style="s2">and notice as we scan<br />out to the right adnexa,</p>
<p begin="00:02:45.983" end="00:02:49.317" style="s2">we notice the presence of<br />a complex, pelvic mass.</p>
<p begin="00:02:49.317" end="00:02:51.160" style="s2">Notice also the relatively low</p>
<p begin="00:02:51.160" end="00:02:53.910" style="s2">serum B-HCG in this case, at 478.</p>
<p begin="00:02:55.640" end="00:02:57.944" style="s2">So, a complex pelvic mass with</p>
<p begin="00:02:57.944" end="00:03:00.337" style="s2">an absence of intrauterine pregnancy.</p>
<p begin="00:03:00.337" end="00:03:03.095" style="s2">Very suspicious for an ectopic pregnancy.</p>
<p begin="00:03:03.095" end="00:03:04.384" style="s2">And what's interesting is,</p>
<p begin="00:03:04.384" end="00:03:07.918" style="s2">as we put Doppler flow on<br />that complex pelvic mass,</p>
<p begin="00:03:07.918" end="00:03:10.715" style="s2">we notice the presence<br />of the ring of fire,</p>
<p begin="00:03:10.715" end="00:03:13.814" style="s2">very suggestive of an ectopic pregnancy</p>
<p begin="00:03:13.814" end="00:03:15.349" style="s2">and the reasons for the ring of fire</p>
<p begin="00:03:15.349" end="00:03:17.280" style="s2">is that the ectopic pregnancy pulls</p>
<p begin="00:03:17.280" end="00:03:19.911" style="s2">a huge amount of vascularity towards it</p>
<p begin="00:03:19.911" end="00:03:20.836" style="s2">and using the Doppler,</p>
<p begin="00:03:20.836" end="00:03:24.188" style="s2">we can see the separate ectopic<br />from the ovary above it.</p>
<p begin="00:03:24.188" end="00:03:26.796" style="s2">Here's another presentation<br />of an ectopic pregnancy.</p>
<p begin="00:03:26.796" end="00:03:28.784" style="s2">Again, we're scanning<br />at a short axis plane</p>
<p begin="00:03:28.784" end="00:03:30.821" style="s2">and we see there the uterus to the left</p>
<p begin="00:03:30.821" end="00:03:34.336" style="s2">and outside the uterus,<br />a separate structure.</p>
<p begin="00:03:34.336" end="00:03:37.471" style="s2">We note here the presence of<br />a thickened Fallopian tube</p>
<p begin="00:03:37.471" end="00:03:39.441" style="s2">and inside the thickened Fallopian tube,</p>
<p begin="00:03:39.441" end="00:03:42.598" style="s2">we see here a fetal<br />pole with a heart beat,</p>
<p begin="00:03:42.598" end="00:03:46.481" style="s2">consistent with a live<br />ampullary ectopic pregnancy.</p>
<p begin="00:03:46.481" end="00:03:47.687" style="s2">Unfortunately in this case,</p>
<p begin="00:03:47.687" end="00:03:49.061" style="s2">the presence of a fetal pole with</p>
<p begin="00:03:49.061" end="00:03:52.671" style="s2">a heart beat is a contraindication<br />of methotrexate therapy</p>
<p begin="00:03:52.671" end="00:03:55.703" style="s2">and this patient will<br />need to undergo surgery.</p>
<p begin="00:03:55.703" end="00:03:57.032" style="s2">We mentioned earlier that there are</p>
<p begin="00:03:57.032" end="00:03:58.694" style="s2">a variance of ectopic pregnancies</p>
<p begin="00:03:58.694" end="00:04:01.961" style="s2">that implant outside the<br />fundal region of the uterus,</p>
<p begin="00:04:01.961" end="00:04:03.804" style="s2">in an aberrant location.</p>
<p begin="00:04:03.804" end="00:04:05.258" style="s2">This is a good example.</p>
<p begin="00:04:05.258" end="00:04:07.557" style="s2">This patient actually<br />has a bicornuate uterus</p>
<p begin="00:04:07.557" end="00:04:10.119" style="s2">and as we scan at a short<br />axis plane up the uterus,</p>
<p begin="00:04:10.119" end="00:04:12.806" style="s2">we notice that the two<br />limbs of endometrium</p>
<p begin="00:04:12.806" end="00:04:15.317" style="s2">that make up the two distinct cornua.</p>
<p begin="00:04:15.317" end="00:04:17.481" style="s2">As we go up the left cornua,</p>
<p begin="00:04:17.481" end="00:04:21.080" style="s2">we notice here the presence<br />of a cornual ectopic pregnancy</p>
<p begin="00:04:21.080" end="00:04:23.857" style="s2">and we see the that it's<br />located off to the side,</p>
<p begin="00:04:23.857" end="00:04:26.139" style="s2">way out to the left cornua,</p>
<p begin="00:04:26.139" end="00:04:28.974" style="s2">with a very thin myometrial mantle.</p>
<p begin="00:04:28.974" end="00:04:30.460" style="s2">If we actually put the calipers down</p>
<p begin="00:04:30.460" end="00:04:32.536" style="s2">and measure the endo-myometrial mantle,</p>
<p begin="00:04:32.536" end="00:04:35.201" style="s2">we find it's very thin,<br />at three millimeters,</p>
<p begin="00:04:35.201" end="00:04:37.397" style="s2">defining an abnormal pregnancy.</p>
<p begin="00:04:37.397" end="00:04:38.608" style="s2">A normal pregnancy should have</p>
<p begin="00:04:38.608" end="00:04:41.622" style="s2">a myometrial mantle greater<br />than eight millimeters.</p>
<p begin="00:04:41.622" end="00:04:43.357" style="s2">Now this is a bicornuate uterus,</p>
<p begin="00:04:43.357" end="00:04:45.266" style="s2">so this is a cornual pregnancy.</p>
<p begin="00:04:45.266" end="00:04:46.599" style="s2">In a normal uterus,</p>
<p begin="00:04:46.599" end="00:04:50.072" style="s2">this would be known as an<br />interstitial pregnancy.</p>
<p begin="00:04:50.072" end="00:04:51.830" style="s2">So in conclusion, I'm glad<br />I could share with you</p>
<p begin="00:04:51.830" end="00:04:54.787" style="s2">this module on ectopic pregnancy part two,</p>
<p begin="00:04:54.787" end="00:04:58.344" style="s2">looking at the varied<br />presentations of ectopic pregnancy.</p>
<p begin="00:04:58.344" end="00:05:00.335" style="s2">Hopefully now you better understand</p>
<p begin="00:05:00.335" end="00:05:02.661" style="s2">what we're searching for<br />on bedside sonography</p>
<p begin="00:05:02.661" end="00:05:03.994" style="s2">when we're working up a patient</p>
<p begin="00:05:03.994" end="00:05:06.558" style="s2">with possible ectopic pregnancy.</p>
<p begin="00:05:06.558" end="00:05:08.212" style="s2">While visualization of the adnexa</p>
<p begin="00:05:08.212" end="00:05:11.035" style="s2">and the Fallopian tubes<br />is an advanced technique,</p>
<p begin="00:05:11.035" end="00:05:12.363" style="s2">but it is well within the scope</p>
<p begin="00:05:12.363" end="00:05:15.764" style="s2">of a busy emergency medicine practice.</p>
<p begin="00:05:15.764" end="00:05:18.466" style="s2">As a final caveat, ectopic pregnancies can</p>
<p begin="00:05:18.466" end="00:05:21.746" style="s2">be seen at Beta-HCG levels<br />ranging from very low,</p>
<p begin="00:05:21.746" end="00:05:25.148" style="s2">less than 100, to very high, above 20,000</p>
<p begin="00:05:25.148" end="00:05:27.526" style="s2">and thus we cannot use a Single Beta-HCG</p>
<p begin="00:05:27.526" end="00:05:30.130" style="s2">level to rule out ectopic pregnancy.</p>
<p begin="00:05:30.130" end="00:05:31.963" style="s2">It's really better to look at trends</p>
<p begin="00:05:31.963" end="00:05:34.439" style="s2">in the hormone level over time.</p>
<p begin="00:05:34.439" end="00:05:36.062" style="s2">With an intrauterine pregnancy,</p>
<p begin="00:05:36.062" end="00:05:38.121" style="s2">the levels should double in 48 hours,</p>
<p begin="00:05:38.121" end="00:05:40.208" style="s2">whereas in most ectopic pregnancy,</p>
<p begin="00:05:40.208" end="00:05:42.712" style="s2">it will not climb to the same degree.</p>
<p begin="00:05:42.712" end="00:05:44.246" style="s2">So, I hope that now you have a</p>
<p begin="00:05:44.246" end="00:05:45.859" style="s2">better understanding of how to</p>
<p begin="00:05:45.859" end="00:05:47.242" style="s2">work up the pregnant patient with</p>
<p begin="00:05:47.242" end="00:05:49.659" style="s2">a possible ectopic pregnancy.</p>
Brightcove ID
5750496732001
https://youtube.com/watch?v=ANhOwzbKe6Y