A popliteal sciatic nerve block done with the Sonosite SII ultrasound machine is a clinically valuable technique that results in anesthesia of the calf, tibia, fibula, ankle, and foot. Anesthesiologist Dr. David Auyong MD of Seattle, Washington here reviews scanning techniques and sonographic landmarks for the procedure, discussing important structures, techniques to visualize the popliteal vein, types of probe used, and needle/injection choices. The Sonosite II allows precise placement of local anesthetic, much reducing patient discomfort, providing superior visualization of the nerve and the needle during block placement.